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Currently Enrolling Alzheimer’s Disease Studies

The success of finding new treatments depends on having enough volunteers like you to participate. To learn how you or a loved one can take part in any of these studies, call  913-588-0555 option 1 for more information, or you may complete the Apply for a Study form online.

KU Alzheimer’s Disease Center Clinical Cohort

A National Institute of Health (NIH) grant funded study to develop and maintain a well characterized group of individual to support further research on memory and aging.

Type of Study: Observational (no treatment)

Who: Individuals with memory loss of any age and individuals without memory loss 65 and older

Procedures: Clinical memory assessment, pen and paper test, blood draw

Duration: up to 3 visits annually

Compensation: No

Relationship of Energetics and Cognitive Trajectory (REACT)

A study to characterize the relationship between metabolic hormone secretion, energy production, and memory.

Type of Study: Observational (no treatment)

Who: Clinical Cohort participants with and without memory loss, age 60 and older

Procedures: Mixed meal tolerance test, blood draws, MRI

Duration: 2 visits

Compensation: Yes

Cerebrovascular Markers for Alzheimer’s Diagnosis (BB8-AD)

A long-term study looking at how vascular health (your heart and blood vessels) may affect memory and brain health. Participants must be enrolled in the KU Alzheimer’s Disease Center Clinical Cohort study.

Type of Study: Observational (no treatment)

Who: Clinical Cohort participants with and without memory loss, age 55-85 years old

Procedures: MRI and PET brain imaging, and vascular measures (ultrasound, blood pressure, artery stiffness)

Duration: Baseline visit and 3 annual follow up visits (not including Clinical Cohort visits)

Compensation: Yes

Alzheimer’s Disease Neuroimaging Initiative 3 (ADNI 3)

A public/private collaboration between academia and industry to study biomarkers and progression of Alzheimer’s disease.

Type of Study: Observational (no treatment)

Who: Individuals with normal cognition ages 65-90 and individuals with Mild Cognitive Impairment or mild Alzheimer’s disease ages 55-90

Procedures: Participants will undergo longitudinal clinical and cognitive assessments, computerized cognitive batteries, biomarker and genetic tests, PET (FDG, amyloid and tau) and MRI scans and cerebral spinal fluid (CSF) collection

Duration: Up to five years, with annual visits

Compensation: Yes

Impact of Statin Therapy on Muscle Mitochondrial Function and Aerobic Capacity (STATINS)

A study to understand the relationship between statin therapy and muscle health, metabolism, and aerobic fitness, which are important factors for healthy aging and brain health.

Type of Study: 1-year statins intervention (chance of placebo)

Who: Individuals 35-65 with normal cognition who are at an increased risk for cardiovascular disease.

Procedures: blood draws, muscle biopsies, fitness tests, body composition scans, glucose tolerance test, pain assessments, physical function assessments.

Duration: 1 year, 12 visits total

Compensation: Yes

Sleep Intervention to Enhance Cognitive Status & Reduce Beta Amyloid (SIESTA)

A study to explore whether cognitive behavioral therapy for insomnia improves cognitive function in older adults and reduces the rate of beta amyloid deposition.

Type of Study: Behavioral intervention (Cognitive Behavioral Therapy for Insomnia)

Who: Individuals age 60-85 with insomnia who are cognitively normal

Procedures: 3 overnight polysomnography visits, 3 cognitive assessment visits, 6 intervention sessions, monthly phone call for 1 year, 2 optional PET/MRI scans

Duration: 15 months (6-week active intervention)

Compensation: Yes

Nutrition Interventions for Cognitive Enhancement (NICE)

A study designed to assess the effect of the Mediterranean versus a low-fat eating plan on brain health

Type of Study: Dietary intervention

Who: Individuals with normal cognition, age 65 and older, with a BMI between 20-40 kg/m2

Procedures: Follow either a Mediterranean or low-fat eating pattern for 1 year, cognitive testing, blood draw, food records, height and weight, waist circumference, questionnaires, and an optional MRI

Duration: 1 year following the assigned eating plan with 7 study visits and 9 nutrition/cooking classes

Compensation: Yes

Placebo-Controlled, Double Blind, Parallel-Group, 18 Month Study with an Open Label Extension Phase to Confirm Safety and Efficacy of BAN2401 in Subjects with Early Alzheimer’s Disease (CLARITY)

A study to evaluate the safety and effectiveness of an investigational medicine (BAN2401) in individuals with Mild

Cognitive Impairment and Alzheimer’s Disease

Type of Study: Investigational medicine (chance of placebo)

Who: Individuals with Mild Cognitive Impairment / Alzheimer’s disease, ages 50-90

Procedures: MRI’s, PET Scan or Lumbar Puncture, pen and paper tests, questionnaires, blood draws, physical exams, infusions

Duration: 2 months of screening; 18 months of infusion visits every 2 weeks; 3 months of follow up or the option to enroll in the Open Label Extension

Compensation: Yes

Randomized Controlled Pilot Trial of Dapagliflozin in Alzheimer’s Disease (DAPA)

Study to investigate the effect of dapagliflozin in participants with probable AD. This study is evaluating the effects of dapagliflozin on n-Acetyl-Aspartate (NAA) levels, blood glucose and insulin levels, mitochondrial function, and cognitive function in people with AD.

Type of Study: Investigational drug (chance of placebo)

Who: Individuals with AD age 50-85

Procedures: Blood draws, PET, MRS (similar to MRI), pen and paper tests, vital signs, DEXA scan, Resting Metabolic Rate, Glucose Tolerance Test

Duration: 14 weeks, about 7 visits

Compensation: Yes

A Dyadic Approach for a Remote Physical Activity Intervention in Adults with Alzheimer’s Disease and their Caregivers (M2G)

Study to test whether group physical activity delivered over the internet can increase activity levels and improve quality of life for individuals with AD and their caregivers.

Type of Study: Weekly group exercise classes or exercise done on own with personal health coach, all done remotely from home.

Who: Individuals with Alzheimer’s Disease age 55 or older and caregivers age 18 or older

Procedures: physical activity monitor, functionality fitness test and fall screener, questionnaires, body measurements (height, weight, and waist circumference), medication record.

Duration: 18 months with 4 in-home visits (6 months active intervention, 6 months maintenance, 6 months no contact follow up).

A randomized Pivotal Study of Renew NCP-5 for the Treatment of Mild Cognitive Impairment due to Alzheimer’s Disease of Mild Dementia of the Alzheimer’s type (ECP)

A study to test the effectiveness of ECP therapy for patients with memory problems from mild cognitive impairment or Alzheimer’s Disease

Type of Study: ECP compared to sham therapy

Who: Individuals with Alzheimer’s Disease or Mild Cognitive Impairment (55-85)

Procedures: ECP therapy, Physical exam, pen and paper, questionnaires, blood draws, vital signs, MRI, ECG, and non-invasive blood flow analysis

Duration: 12 months (6 months treatment with 2-5 visits per week; 6 months follow up with 1 phone call and 1 visit)

Compensation: Yes

Therapeutic Diets in Alzheimer’s Disease (TDAD)

A study to determine the effect of a ketogenic diet (KD) on cognition and function in Alzheimer’s Disease and to define KD physiological effects and mechanisms of action.

Type: Diet intervention

Who: Individuals with very mild to mild Alzheimer’s Disease and a study partner

Procedures: Physical exam, blood draws, questionnaires, cognitive testing, MRI, urine testing

Duration: 3 months of diet intervention and one-month follow-up phone call with up to 7 visits to the CTSU and Hoglund Imaging Center on main campus

Compensation: Yes

 

The mission of the KU Alzheimer's Disease Center is to improve the lives of patients and families with Alzheimer's disease by eliminating the disease through research into its treatment and prevention.

Join our team – Make an impact - Become a Research Hero

Last modified: Jun 16, 2020
How to Join

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Questions?

Email KUAMP@kumc.edu

or call (913) 588-0555.

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